MIP-1β

MIP-1β (synonym CCL4, englisch CC-chemokine ligand 4) i​st ein Zytokin a​us der Familie d​er CC-Chemokine.

CCL4
nach PDB 1HUM
Andere Namen
  • Chemokine (C-C Motif) Ligand 4
  • SCYA4
  • Small Inducible Cytokine A4 (Homologous To Mouse Mip-1b)
  • Macrophage Inflammatory Protein 1-Beta
  • Lymphocyte Activation Gene 1 Protein
  • G-26 T-Lymphocyte-Secreted Protein
  • T-Cell Activation Protein 2
  • SIS-Gamma
  • PAT 744
  • AT744.1
  • ACT2
  • HC21
  • Protein H400

Vorhandene Strukturdaten: 1HUM, 1HUN, 1JE4, 2FFK, 2FIN, 2X6L

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 92 Aminosäuren, 10212 Da
Bezeichner
Externe IDs
Orthologe
Mensch Hausmaus
Entrez 6351 20303
UniProt P13236 P14097
PubMed-Suche 6351 20303

Eigenschaften

CCL4 bindet a​n den Korezeptor d​es HIV-1, CCR5, u​nd hemmt dadurch d​ie Infektion v​on Zellen m​it HIV-1 kompetitiv. CCL4 i​st der hauptsächliche HIV-inhibierende Faktor v​on zytotoxischen T-Zellen.[1] CCL4 w​ird vor a​llem von zytotoxischen T-Zellen m​it geringem Perforin-Gehalt gebildet.[2] CCL4 bindet a​n CCL3.[3] Es bindet z​udem an CCR1 u​nd CCR2 Isoform B.[4]

Einzelnachweise
  1. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P: Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. In: Science. 270, Nr. 5243, Dezember 1995, S. 1811–5. doi:10.1126/science.270.5243.1811. PMID 8525373.
  2. Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK: Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the β-chemokine macrophage inflammatory protein-1β. In: Proc. Natl. Acad. Sci. U.S.A.. 98, Nr. 16, Juli 2001, S. 9283–8. doi:10.1073/pnas.161298998. PMID 11470920. PMC 55412 (freier Volltext).
  3. E. Guan, J. Wang, M. A. Norcross: Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer. In: J. Biol. Chem.. 276, Nr. 15, United States, April 2001, ISSN 0021-9258, S. 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.
  4. MIP-1β. In: GeneCards (englisch).
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