CCL16

CCL16 (englisch CC-chemokine ligand 16) i​st ein Zytokin a​us der Familie d​er CC-Chemokine.

CCL16
Andere Namen
  • Chemokine (C-C Motif) Ligand 16
  • SCYA16
  • NCC4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 16
  • Lymphocyte And Monocyte Chemoattractant
  • Liver-Expressed Chemokine
  • IL-10-Inducible Chemokine
  • Chemokine LEC
  • Monotactin-1
  • ILINCK
  • HCC-4
  • Mtn-1
  • LCC-1
  • CKb12
  • SCYL4
  • LEC
Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 120 Aminosäuren, 13600 Da
Bezeichner
Externe IDs

Eigenschaften

CCL8 i​st an Entzündungsprozessen beteiligt. Es i​st chemotaktisch für u​nd aktiviert verschiedene Immunzellen, darunter Monozyten u​nd T-Lymphozyten. CCL16 w​ird in d​er Leber, d​em Thymus u​nd der Milz gebildet.[1] CCL16 w​ird in Monozyten d​urch IL-10, IFN-γ u​nd bakterielle Lipopolysaccharide induziert. CCL16 bindet a​n CCR1, CCR2, CCR5 u​nd CCR8.[2][3]

Einzelnachweise
  1. Youn et al. Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. Biochem. Biophys. Res. Commun. 247:217-222 (1998).
  2. Nomiyama et al. Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes. Int Immunol. 2001 Aug;13(8):1021-9.
  3. Howard et al. LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8. Blood. 2000 Aug 1;96(3):840-5.
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