CCL24

CCL24
Andere Namen	Chemokine (C-C Motif) Ligand 24; Myeloid Progenitor Inhibitory Factor 2; CK-Beta-6; Eotaxin-2; SCYA24; MPIF2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 24; Eosinophil Chemotactic Protein 2; Ckb-6;
	Vorhandene Strukturdaten: 1EIG, 1EIH
Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur	119 Aminosäuren, 13134 Da
Bezeichner
Externe IDs	GeneCards: CCL24; OMIM: 602495; UniProt: O00175;
	Orthologe

CCL24 (englisch CC-chemokine ligand 24) ist ein Zytokin aus der Familie der CC-Chemokine.

Eigenschaften

CCL24 ist an Entzündungsprozessen beteiligt. Es bindet an CCR3 und ist chemotaktisch für Eosinophile,[1] ruhende T-Zellen und in geringerem Umfang auch für Neutrophile.[2] CCL24 ist an der Entstehung von Acetylsalicylsäure-induziertem Asthma beteiligt.[3]

Einzelnachweise

White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM: Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. In: J. Leukoc. Biol.. 62, Nr. 5, November 1997, S. 667–75. PMID 9365122.
Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G: Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. In: J. Exp. Med.. 185, Nr. 7, April 1997, S. 1163–72. doi:10.1084/jem.185.7.1163. PMID 9104803. PMC 2196270 (freier Volltext).
Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS: Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease. In: Allergy. 65, Nr. 3, October 2009, S. 338–346. doi:10.1111/j.1398-9995.2009.02158.x. PMID 19796209.

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[pmid9365122-1] White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM: Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. In: J. Leukoc. Biol.. 62, Nr. 5, November 1997, S. 667–75. PMID 9365122.

[pmid9104803-2] Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G: Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. In: J. Exp. Med.. 185, Nr. 7, April 1997, S. 1163–72. doi:10.1084/jem.185.7.1163. PMID 9104803. PMC 2196270 (freier Volltext).

[pmid19796209-3] Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS: Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease. In: Allergy. 65, Nr. 3, October 2009, S. 338–346. doi:10.1111/j.1398-9995.2009.02158.x. PMID 19796209.