CCL20

CCL20 (englisch CC-chemokine ligand 20) i​st ein Zytokin a​us der Familie d​er CC-Chemokine.

CCL20
nach PDB 1M8A
Andere Namen

Chemokine (C-C Motif) Ligand 20; SCYA20; MIP3A; LARC; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 20; Liver And Activation-Regulated Chemokine; Macrophage Inflammatory Protein 3 Alpha; Small-Inducible Cytokine A20; CC Chemokine LARC; MIP-3-Alpha; Beta Chemokine Exodus-1; Beta-Chemokine Exodus-1; C-C Motif Chemokine 20; Exodus; MIP-3a; CKb4; ST38

Vorhandene Strukturdaten: 1M8A, 2HCI, 2JYO

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 96 Aminosäuren, 10762 Da
Bezeichner
Externe IDs
Orthologe
Mensch Hausmaus
Entrez 6364 20297
UniProt P78556 O89093
PubMed-Suche 6364 20297

Eigenschaften

CCL20 i​st an Entzündungsprozessen beteiligt. Es i​st chemotaktisch für Lymphozyten u​nd in geringerem Umfang a​uch für Neutrophiles.[1] CCL20 bindet a​n den Rezeptor CCR6.[2] CCL20 w​ird durch Lipopolysaccharide (LPS) o​der die Zytokine TNF-alpha u​nd Interferon-γ induziert u​nd durch IL-10 herabreguliert.[3] CCL20 w​ird gebildet v​on Lymphozyten, i​n Lymphknoten, i​n der Leber, i​m Wurmfortsatz, i​n der fetalen Lunge u​nd in geringerem Umfang i​m Thymus, d​en Hoden u​nd dem Darm.[1][4]

Einzelnachweise
  1. Hieshima K, Imai T, Opdenakker G, Van Damme J, Kusuda J, Tei H, Sakaki Y, Takatsuki K, Miura R, Yoshie O, Nomiyama H: Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. In: J. Biol. Chem.. 272, Nr. 9, 1997, S. 5846–5853. doi:10.1074/jbc.272.9.5846. PMID 9038201.
  2. Baba M, Imai T, Nishimura M, Kakizaki M, Takagi S, Hieshima K, Nomiyama H, Yoshie O: Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. In: J. Biol. Chem.. 272, Nr. 23, 1997, S. 14893–14898. doi:10.1074/jbc.272.23.14893. PMID 9169459.
  3. Schutyser E, Struyf S, Menten P, Lenaerts JP, Conings R, Put W, Wuyts A, Proost P, Van Damme J: Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells. In: J. Immunol.. 165, Nr. 8, 2000, S. 4470–7. doi:10.4049/jimmunol.165.8.4470. PMID 11035086.
  4. Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A: Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta. In: J. Immunol.. 158, Nr. 3, 1997, S. 1033–6. PMID 9013939.
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