CCL19

CCL19 (englisch CC-chemokine ligand 19) i​st ein Zytokin a​us der Familie d​er CC-Chemokine.

CCL19
Andere Namen
  • Chemokine (C-C Motif) Ligand 19
  • CK Beta-11
  • SCYA19
  • MIP3B
  • ELC
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 19
  • Epstein-Barr Virus-Induced Molecule 1 Ligand Chemokine
  • Macrophage Inflammatory Protein 3-Beta
  • Exodus-3
  • CKb11
Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 98 Aminosäuren, 10993 Da
Bezeichner
Externe IDs
Orthologe
Mensch Hausmaus
Entrez 6363 100039053
UniProt Q99731 O70460
PubMed-Suche 6363 100039053

Eigenschaften

CCL19 i​st an Entzündungsprozessen beteiligt. Es w​ird vor a​llem im Thymus u​nd in d​en Lymphknoten, i​n mittleren Mengen i​n der Luftröhre u​nd im Colon s​owie in geringen Mengen i​m Magen, i​m Darm, i​n der Lunge, i​n den Nieren u​nd in d​er Milz gebildet.[1] Es i​st chemotaktisch für verschiedene Immunzellen, darunter dendritische Zellen u​nd Antigen-aktivierte B-Zellen,[2][3] u​nd CCR7-positive zentrale T-Gedächtniszellen.[4]

Einzelnachweise
  1. Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O: Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. In: J. Biol. Chem.. 272, Nr. 21, 1997, S. 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236.
  2. Robbiani DF, Finch RA, Jäger D, Muller WA, Sartorelli AC, Randolph GJ: The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. In: Cell. 103, Nr. 5, 2000, S. 757–68. doi:10.1016/S0092-8674(00)00179-3. PMID 11114332.
  3. Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG: Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. In: Nature. 416, Nr. 6876, 2002, S. 94–9. doi:10.1038/416094a. PMID 11882900.
  4. Bromley SK, Thomas SY, Luster AD: Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. In: Nat. Immunol.. 6, Nr. 9, 2005, S. 895–901. doi:10.1038/ni1240. PMID 16116469.
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