CCL15

CCL15
Andere Namen	Chemokine (C-C Motif) Ligand 15; Macrophage Inflammatory Protein 5; Chemokine CC-2; MIP-1 Delta; SCYA15; NCC3; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 15; Leukotactin 1; MRP-2B; HCC-2; LKN-1; MIP-5; HMRP-2B; SY15;
	Vorhandene Strukturdaten: 2HCC
Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur	113 Aminosäuren, 12248 Da
Bezeichner
Externe IDs	GeneCards: CCL15; OMIM: 601393; UniProt: Q16663;

CCL15 (englisch CC-chemokine ligand 15) ist ein Zytokin aus der Familie der CC-Chemokine.

Eigenschaften

CCL15 ist an Entzündungsprozessen beteiligt. Es ist chemotaktisch für und aktiviert verschiedene Immunzellen, darunter Neutrophile, Monozyten und T-Zellen. CCL15 wird in der Leber, im Darm und in Leukozyten und Makrophagen der Lunge gebildet.[1] CCL15 bindet an CCR1 und CCR3.[2][3]

Einzelnachweise

Pardigol et al. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Proc. Nat. Acad. Sci. 95: 6308-6313, 1998.
Youn et al. Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J. Immun. 159: 5201-5205, 1997.
Coulin et al. Characterization of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines. Europ. J. Biochem. 248: 507-515, 1997.

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[1] Pardigol et al. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Proc. Nat. Acad. Sci. 95: 6308-6313, 1998.

[2] Youn et al. Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J. Immun. 159: 5201-5205, 1997.

[3] Coulin et al. Characterization of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines. Europ. J. Biochem. 248: 507-515, 1997.