CCL13

CCL13 (englisch CC-chemokine ligand 13) i​st ein Zytokin a​us der Familie d​er CC-Chemokine.

CCL13
Andere Namen
  • Chemokine (C-C Motif) Ligand 13
  • SCYA13
  • NCC1
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 13
  • Monocyte Chemoattractant Protein 4
  • Monocyte Chemotactic Protein 4
  • Small-Inducible Cytokine A13
  • CK-Beta-10
  • MCP-4
  • NCC-1
  • CKb10
  • SCYL1

Vorhandene Strukturdaten: 2RA4

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 98 Aminosäuren, 10986 Da
Bezeichner
Externe IDs
Orthologe
Mensch Hausmaus
Entrez 6357 20296
UniProt Q99616 P10148
PubMed-Suche 6357 20296

Eigenschaften

CCL8 i​st an Entzündungsprozessen beteiligt. Es i​st chemotaktisch für u​nd aktiviert verschiedene Immunzellen, darunter Monozyten, Eosinophile, T-Lymphozyten u​nd Basophile d​urch Bindung a​n CCR2, CCR3 u​nd CCR5.[1] CCL13 i​st an d​er Entstehung v​on Asthma beteiligt.[2] CCL13 w​ird durch d​ie Zytokine Interleukin-1 u​nd TNF-α induziert.

Einzelnachweise
  1. Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94:1899-905.
  2. Lamkhioued et al., Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Am J Respir Crit Care Med. 2000, 162:723-32.
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