CCL11

CCL11
	nach PDB 1EOT
Andere Namen	Chemokine (C-C Motif) Ligand 11; SCYA11; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 11 (Eotaxin); Eosinophil Chemotactic Protein; Eotaxin-1;
	Vorhandene Strukturdaten: 1EOT, 2EOT, 2MPM
Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur	97 Aminosäuren, 10732 Da
Bezeichner
Externe IDs	GeneCards: CCL11; OMIM: 601156; UniProt: P51671;
	Orthologe

CCL11 (englisch CC-chemokine ligand 11) ist ein Zytokin aus der Familie der CC-Chemokine.

Eigenschaften

CCL11 ist an Entzündungsprozessen beteiligt. Es ist chemotaktisch für Eosinophile.[1][2][3] CCL11 bindet an CCR2,[4] CCR3[5] und CCR5.[4]

Einzelnachweise

Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty NF, Truong O, Hsuan JJ, Williams TJ: Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation.. In: J. Exp Med.. 179, Nr. 3, 1994, S. 881–7. doi:10.1084/jem.179.3.881. PMID 7509365. PMC 2191401 (freier Volltext).
Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR: Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. In: J. Clin. Invest.. 97, Nr. 3, 1996, S. 604–12. doi:10.1172/JCI118456. PMID 8609214. PMC 507095 (freier Volltext).
Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD: Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. In: Nat. Med.. 2, Nr. 4, 1996, S. 449–56. doi:10.1038/nm0496-449. PMID 8597956.
Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M: Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5. In: Blood. 97, Nr. 7, 2001, S. 1920–4. doi:10.1182/blood.V97.7.1920. PMID 11264152.
Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O: Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. In: J. Biol. Chem.. 271, Nr. 13, 1996, S. 7725–30. doi:10.1074/jbc.271.13.7725. PMID 8631813.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. The authors of the article are listed here. Additional terms may apply for the media files, click on images to show image meta data.

[pmid7509365-1] Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty NF, Truong O, Hsuan JJ, Williams TJ: Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation.. In: J. Exp Med.. 179, Nr. 3, 1994, S. 881–7. doi:10.1084/jem.179.3.881. PMID 7509365. PMC 2191401 (freier Volltext).

[pmid8609214-2] Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR: Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. In: J. Clin. Invest.. 97, Nr. 3, 1996, S. 604–12. doi:10.1172/JCI118456. PMID 8609214. PMC 507095 (freier Volltext).

[pmid8597956-3] Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD: Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. In: Nat. Med.. 2, Nr. 4, 1996, S. 449–56. doi:10.1038/nm0496-449. PMID 8597956.

[pmid11264152-4] Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M: Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5. In: Blood. 97, Nr. 7, 2001, S. 1920–4. doi:10.1182/blood.V97.7.1920. PMID 11264152.

[pmid8631813-5] Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O: Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. In: J. Biol. Chem.. 271, Nr. 13, 1996, S. 7725–30. doi:10.1074/jbc.271.13.7725. PMID 8631813.