Tyrosinkinase Fyn

Die Tyrosinkinase Fyn i​st ein Enzym i​n Wirbeltieren, d​as die Phosphorylierung mehrerer Proteine a​n der Aminosäure Tyrosin katalysiert (Tyrosinkinase). Diese Reaktion i​st Teil v​on etwa e​inem Dutzend Signalwege, d​ie unentbehrlich für d​ie Embryonalentwicklung d​es Gehirns u​nd dessen spätere Funktion sind. Beim Menschen kontrolliert Fyn d​as Wachstum d​er Axone u​nd den Calciumgehalt v​on Zellen. Von d​en drei bekannten Isoformen w​ird 'B' besonders i​m Gehirn u​nd 'T' i​n T-Zellen exprimiert.[2]

Tyrosinkinase Fyn
Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 537 Aminosäuren
Kofaktor Mn2+
Isoformen B, T, P06421-3
Bezeichner
Gen-Name FYN
Externe IDs
Enzymklassifikation
EC, Kategorie 2.7.10.2, Tyrosinkinase
Reaktionsart Phosphorylierung von Tyrosinresten in Proteinen
Substrat Xaa-Tyr-Yaa + ATP
Produkte Xaa-TyrP-Yaa + ADP
Vorkommen
Übergeordnetes Taxon Wirbeltiere[1]
Orthologe
Mensch Hausmaus
Entrez 2534 14360
Ensembl ENSG00000010810 ENSMUSG00000019843
UniProt P06241 P39688
Refseq (mRNA) NM_002037 NM_001122892
Refseq (Protein) NP_002028 NP_001116364
Genlocus Chr 6: 111.66 – 111.87 Mb Chr 10: 39.37 – 39.57 Mb
PubMed-Suche 2534 14360

Interaktionen

Für FYN wurden einige Interaktionen m​it anderen Proteinen nachgewiesen.

Literatur

Quellen, Zitatnachweise, Zeitschriftenartikel
  1. Orthologe bei OMA
  2. UniProt P06421
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