CXCL1

CXCL1 i​st ein Zytokin a​us der Familie d​er CXC-Chemokine.

CXCL1
nach PDB 1MGS
Andere Namen
  • Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha)
  • GRO1 Oncogene (Melanoma Growth Stimulating Activity, Alpha)
  • Neutrophil-Activating Protein 3
  • Fibroblast Secretory Protein
  • GRO-Alpha(1-73)
  • NAP-3
  • SCYB1
  • GRO1
  • MGSA Alpha
  • FSP

Vorhandene Strukturdaten: 1MGS, 1MSG, 1MSH, 1ROD

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 107 Aminosäuren, 11301 Da
Bezeichner
Externe IDs

Eigenschaften

CXCL1 w​ird unter anderem v​on Makrophagen, Neutrophilen u​nd Epithelzellen gebildet.[1][2] CXCL1 bindet Neutrophile a​n Orten d​er Entzündung.[3][4] CXCL1 i​st an d​er Entwicklung d​es Rückenmarks (hemmt d​ort die Wanderung d​er Oligodendrozyten-Vorläuferzellen), d​er Angiogenese, d​er Entzündung, d​er Wundheilung u​nd der Entstehung v​on Tumoren beteiligt.[5][6][7][8]

CXCL1 i​st mitogen u​nd an d​er Pathogenese v​on Melanomen beteiligt.[9][10]

CXCL1 w​ird durch d​en Rezeptor CXCR2 gebunden.[5] Das CXCL1-Gen l​iegt in e​inem Gen-Cluster m​it Genen v​on anderen CXC-Chemokinen.[11]

Einzelnachweise
  1. N. Iida, G. R. Grotendorst: Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. In: Mol. Cell. Biol.. 10, Nr. 10, Oktober 1990, S. 5596–5599. PMID 2078213. PMC 361282 (freier Volltext).
  2. S. Becker, J. Quay, H. S. Koren, J. S. Haskill: Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. In: Am. J. Physiol.. 266, Nr. 3 Pt 1, März 1994, S. L278–L286. PMID 8166297.
  3. B. Moser, I. Clark-Lewis, R. Zwahlen, M. Baggiolini: Neutrophil-activating properties of the melanoma growth-stimulatory activity. In: J. Exp. Med.. 171, Nr. 5, Mai 1990, S. 1797–1802. doi:10.1084/jem.171.5.1797. PMID 2185333. PMC 2187876 (freier Volltext).
  4. C. Schumacher, I. Clark-Lewis, M. Baggiolini, B. Moser: High- and low-affinity binding of GRO alpha and neutrophil-activating peptide 2 to interleukin 8 receptors on human neutrophils. In: Proc. Natl. Acad. Sci. U.S.A.. 89, Nr. 21, November 1992, S. 10542–10546. doi:10.1073/pnas.89.21.10542. PMID 1438244. PMC 50375 (freier Volltext).
  5. H. H. Tsai, E. Frost, V. To, S. Robinson, C. Ffrench-Constant, R. Geertman, R. M. Ransohoff, R. H. Miller: The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. In: Cell. 110, Nr. 3, August 2002, S. 373–383. doi:10.1016/S0092-8674(02)00838-3. PMID 12176324.
  6. R. M. Devalaraja, L. B. Nanney, J. Du, Q. Qian, Y. Yu, M. N. Devalaraja, A. Richmond: Delayed wound healing in CXCR2 knockout mice. In: J. Invest. Dermatol.. 115, Nr. 2, August 2000, S. 234–244. doi:10.1046/j.1523-1747.2000.00034.x. PMID 10951241. PMC 2664868 (freier Volltext).
  7. H. Haghnegahdar, J. Du, D. Wang, R. M. Strieter, M. D. Burdick, L. B. Nanney, N. Cardwell, J. Luan, R. Shattuck-Brandt, A. Richmond: The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma. In: J. Leukoc. Biol.. 67, Nr. 1, Januar 2000, S. 53–62. PMID 10647998. PMC 2669312 (freier Volltext).
  8. J. D. Owen, R. Strieter, M. Burdick, H. Haghnegahdar, L. Nanney, R. Shattuck-Brandt, A. Richmond: Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteins. In: Int. J. Cancer. 73, Nr. 1, September 1997, S. 94–103. doi:10.1002/(SICI)1097-0215(19970926)73:1<94::AID-IJC15>3.0.CO;2-5. PMID 9334815.
  9. A. Anisowicz, L. Bardwell, R. Sager: Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells. In: Proc. Natl. Acad. Sci. U.S.A.. 84, Nr. 20, October 1987, S. 7188–7192. doi:10.1073/pnas.84.20.7188. PMID 2890161. PMC 299255 (freier Volltext).
  10. A. Richmond, H. G. Thomas: Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution. In: J. Cell. Biochem.. 36, Nr. 2, Februar 1988, S. 185–198. doi:10.1002/jcb.240360209. PMID 3356754.
  11. A. Richmond, E. Balentien, H. G. Thomas, G. Flaggs, D. E. Barton, J. Spiess, R. Bordoni, U. Francke, R. Derynck: Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. In: EMBO J.. 7, Nr. 7, Juli 1988, S. 2025–2033. PMID 2970963. PMC 454478 (freier Volltext).
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