CCL9

CCL9 (englisch CC-chemokine ligand 9) ist ein Zytokin aus der Familie der CC-Chemokine.

Eigenschaften

CCL9 ist an Entzündungsprozessen beteiligt. Es wird von Lymphfollikel-assoziiertem Gewebe wie z. B. um Peyersche Plaques gebildet und bindet Dendritische Zellen über ihr Integrin alpha M (synonym CD11b) und den Chemokinrezeptor CCR1.[1] CCL9 aktiviert Osteoklasten über ihren Rezeptor CCR1.[2] CCL9 wird konstitutiv von Makrophagen und myeloischen Zellen gebildet.[3][4] CCL9 wurde auch als CCL10 bezeichnet.

Einzelnachweise

Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A: CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. In: J Immunol. 171, Nr. 6, 2003, S. 2797–803. doi:10.4049/jimmunol.171.6.2797. PMID 12960300.
Lean J, Murphy C, Fuller K, Chambers T: CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts. In: J Cell Biochem. 87, Nr. 4, 2002, S. 386–93. doi:10.1002/jcb.10319. PMID 12397598.
Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B: A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors. In: J Immunol. 155, Nr. 5, 1995, S. 2661–7. PMID 7650394.
Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A: Molecular cloning and functional characterization of a novel member of the C-C chemokine family. In: J Immunol. 155, Nr. 11, 1995, S. 5352–8. PMID 7594550.

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[1] Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A: CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. In: J Immunol. 171, Nr. 6, 2003, S. 2797–803. doi:10.4049/jimmunol.171.6.2797. PMID 12960300.

[2] Lean J, Murphy C, Fuller K, Chambers T: CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts. In: J Cell Biochem. 87, Nr. 4, 2002, S. 386–93. doi:10.1002/jcb.10319. PMID 12397598.

[3] Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B: A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors. In: J Immunol. 155, Nr. 5, 1995, S. 2661–7. PMID 7650394.

[hara-4] Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A: Molecular cloning and functional characterization of a novel member of the C-C chemokine family. In: J Immunol. 155, Nr. 11, 1995, S. 5352–8. PMID 7594550.