CCL27

CCL27 (englisch CC-chemokine ligand 27) i​st ein Zytokin a​us der Familie d​er CC-Chemokine.

CCL27
Andere Namen
  • Chemokine (C-C Motif) Ligand 27
  • CC Chemokine ILC
  • SCYA27
  • CTACK
  • ILC
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 27
  • Cutaneous T-Cell Attracting Chemokine
  • IL-11 R-Alpha-Locus Chemokine
  • Skinkine
  • ESKINE
  • PESKY
  • CTAK
  • ALP

Vorhandene Strukturdaten: 2KUM

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 112 Aminosäuren, 12618 Da
Bezeichner
Externe IDs
Orthologe
Mensch Hausmaus
Entrez 10850 100861978
UniProt Q9Y4X3 Q9Z1X0
PubMed-Suche 10850 100861978

Eigenschaften

CCL27 i​st an Entzündungsprozessen beteiligt. Es i​st chemotaktisch für T-Gedächtniszellen u​nd bindet s​ie über d​en Rezeptor CCR10 u​nter anderem i​n der Haut.[1][2][3] CCL27 w​ird in d​en Gonaden, i​m Thymus, i​n der Plazenta u​nd in d​er Haut gebildet.

Einzelnachweise
  1. Homey et al. The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J. Immunol. 164:3465-3470, 2000.
  2. Morales et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. U.S.A. 96:14470-14475, 1999.
  3. Homey et al. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nature Med. 8: 157-165, 2002.
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