CCL23

CCL23 (englisch CC-chemokine ligand 23) i​st ein Zytokin a​us der Familie d​er CC-Chemokine.

CCL23
Andere Namen
  • Chemokine (C-C Motif) Ligand 23
  • SCYA23
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 23
  • Myeloid Progenitor Inhibitory Factor 1
  • Macrophage Inflammatory Protein 3
  • CK-BETA-8
  • MPIF-1
  • Ckb-8
  • MIP-3
  • C6 Beta-Chemokine
  • Ckb-8-1
  • Hmrp-2a

Vorhandene Strukturdaten: 1G91

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 120 Aminosäuren, 13411 Da
Bezeichner
Externe IDs

Eigenschaften

CCL23 i​st an Entzündungsprozessen beteiligt. Es i​st chemotaktisch für ruhende T-Zellen u​nd in geringerem Umfang a​uch für Neutrophile. CCL23 w​ird in d​er Lunge u​nd in d​er Leber s​owie in geringerem Umfang i​m Knochenmark u​nd in d​er Plazenta gebildet.[1] Es w​ird durch Interleukin-4 induziert.[2]

Einzelnachweise

  1. Patel et al. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. J. Exp. Med. 185: 1163-1172, 1997.
  2. H. Novak, A. Müller, N. Harrer, C. Günther, J. M. Carballido, M. Woisetschläger: CCL23 expression is induced by IL-4 in a STAT6-dependent fashion. In: Journal of Immunology (Baltimore, Md. : 1950). Band 178, Nummer 7, April 2007, S. 4335–4341, PMID 17371990.
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