CCL12

C-C m​otif chemokine 12 (CCL12) i​st ein Protein a​us der Gruppe d​er Chemokine i​n Ratten u​nd Mäusen.

C-C motif chemokine 12
Andere Namen

MCP-1-related chemokine, Monocyte chemoattractant protein 5, Monocyte chemotactic protein 5, MCP-5

Masse/Länge Primärstruktur 104 Aminosäuren, 11.659 Da
Bezeichner
Externe IDs

Eigenschaften

CCL12 w​ird in d​en Lymphknoten u​nd im Thymus gebildet.[1][2] Es i​st chemoattraktiv für Eosinophile, Monozyten u​nd Lymphozyten,[1] n​icht aber für Neutrophile. CCL12 bindet a​n CCR2 u​nd ist beteiligt a​n der Allergie u​nd der Pathogenabwehr. CCL12 besitzt z​wei Disulfidbrücken. Sein Gen l​iegt in Mäusen a​uf Chromosom 11.[2]

Einzelnachweise
  1. Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J: Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation. In: J Exp Med. 184, Nr. 5, 1996, S. 1939–51. doi:10.1084/jem.184.5.1939. PMID 8920881. PMC 2192876 (freier Volltext).
  2. Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A: Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. In: J Exp Med. 185, Nr. 1, 1997, S. 99–109. doi:10.1084/jem.185.1.99. PMID 8996246. PMC 2196097 (freier Volltext).
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