Adipokine

Adipokine sind eine Gruppe endokrin aktiver Proteine aus dem Fettgewebe, wie Cytokine oder Peptidhormone. Das erste Adipokin wurde 1994 entdeckt, Leptin.[1] Seitdem wurden über hundert Adipokine beschrieben.[2] Beispiele für Adipokine sind Leptin, Adiponectin, Apelin,[3] Chemerin,[4] Interleukin-6 (IL-6),[5] monocyte chemotactic protein-1 (MCP-1),[6] Plasminogen activator inhibitor-1 (PAI-1), Retinol binding protein 4 (RBP4), TNF-α, Visfatin, Omentin, Vaspin, Progranulin, CTRP-4.

Adipokine besitzen entzündungsfördernde oder -hemmende Eigenschaften und verbinden den Stoffwechsel mit dem Immunsystem.[7] Bei Hunger nehmen entzündungshemmende Adipokine zu und entzündungsfördernde ab, bei Gewichtszunahme umgekehrt.[7]

Entzündungsfördernde Adipokine sind an der Entstehung von Diabetes mellitus Typ II, Arteriosklerose und Bluthochdruck beteiligt.[8][9]

Weblinks

MeSH Adipokine

Einzelnachweise

J. Conde, M. Scotece, R. Gómez, V. López, J. J. Gómez-Reino, F. Lago, O. Gualillo: Adipokines: biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity. In: BIOFACTORS. Band 37, Nr. 6, 2011, S. 413–420, doi:10.1002/biof.185, PMID 22038756.
S. Lehr, S. Hartwig, H. Sell: Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders. In: Proteomics Clinical Applications. Band 6, Nr. 1-2, 2012, S. 91–101, doi:10.1002/prca.201100052, PMID 22213627.
L. Guo, Q. Li, W. Wang, P. Yu, H. Pan, P. Li, Y. Sun, J. Zhang: Apelin Inhibits Insulin Secretion in Pancreatic β-Cells by Activation of PI3-Kinase-Phosphodiesterase 3B. In: Endocr Res. 34(4), 2009, S. 142–154.
Ormond A. MacDougald, Charles F. Burant: The Rapidly Expanding Family of Adipokines. In: Cell Metabolism. 6, September 2007, S. 159–161.
Lais U. Monzillo: Effect of Lifestyle Modification on Adipokine Levels in Obese Subjects with Insulin Resistance. In: Obesity Research. 11(9) 2003, S. 1048–1054.
T. Christiansen, B. Richelsen, J. M. Bruun: Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. In: International Journal of Obesity. 29 2005, S. 146–150.
P. Mancuso: The role of adipokines in chronic inflammation. In: ImmunoTargets and therapy. Band 5, 2016, S. 47–56, doi:10.2147/ITT.S73223. PMID 27529061, PMC 4970637 (freier Volltext)
L. C. Freitas Lima, V. A. Braga, M. do Socorro de França Silva, J. C. Cruz, S. H. Sousa Santos, M. M. de Oliveira Monteiro, C. M. Balarini: Adipokines, diabetes and atherosclerosis: an inflammatory association. In: Frontiers in physiology. Band 6, 2015, S. 304, doi:10.3389/fphys.2015.00304. PMID 26578976, PMC 4630286 (freier Volltext).
Y. Deng, P. E. Scherer: Adipokines as novel biomarkers and regulators of the metabolic syndrome. In: Annals of the New York Academy of Sciences. Band 1212, November 2010, S. E1–E19, doi:10.1111/j.1749-6632.2010.05875.x. PMID 21276002, PMC 3075414 (freier Volltext).

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[pmid22038756-1] J. Conde, M. Scotece, R. Gómez, V. López, J. J. Gómez-Reino, F. Lago, O. Gualillo: Adipokines: biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity. In: BIOFACTORS. Band 37, Nr. 6, 2011, S. 413–420, doi:10.1002/biof.185, PMID 22038756.

[pmid22213627-2] S. Lehr, S. Hartwig, H. Sell: Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders. In: Proteomics Clinical Applications. Band 6, Nr. 1-2, 2012, S. 91–101, doi:10.1002/prca.201100052, PMID 22213627.

[3] L. Guo, Q. Li, W. Wang, P. Yu, H. Pan, P. Li, Y. Sun, J. Zhang: Apelin Inhibits Insulin Secretion in Pancreatic β-Cells by Activation of PI3-Kinase-Phosphodiesterase 3B. In: Endocr Res. 34(4), 2009, S. 142–154.

[4] Ormond A. MacDougald, Charles F. Burant: The Rapidly Expanding Family of Adipokines. In: Cell Metabolism. 6, September 2007, S. 159–161.

[5] Lais U. Monzillo: Effect of Lifestyle Modification on Adipokine Levels in Obese Subjects with Insulin Resistance. In: Obesity Research. 11(9) 2003, S. 1048–1054.

[6] T. Christiansen, B. Richelsen, J. M. Bruun: Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. In: International Journal of Obesity. 29 2005, S. 146–150.

[Mancuso-7] P. Mancuso: The role of adipokines in chronic inflammation. In: ImmunoTargets and therapy. Band 5, 2016, S. 47–56, doi:10.2147/ITT.S73223. PMID 27529061, PMC 4970637 (freier Volltext)

[8] L. C. Freitas Lima, V. A. Braga, M. do Socorro de França Silva, J. C. Cruz, S. H. Sousa Santos, M. M. de Oliveira Monteiro, C. M. Balarini: Adipokines, diabetes and atherosclerosis: an inflammatory association. In: Frontiers in physiology. Band 6, 2015, S. 304, doi:10.3389/fphys.2015.00304. PMID 26578976, PMC 4630286 (freier Volltext).

[9] Y. Deng, P. E. Scherer: Adipokines as novel biomarkers and regulators of the metabolic syndrome. In: Annals of the New York Academy of Sciences. Band 1212, November 2010, S. E1–E19, doi:10.1111/j.1749-6632.2010.05875.x. PMID 21276002, PMC 3075414 (freier Volltext).