CCL2

CCL2 (englisch CC-chemokine ligand 2 ‚CC-Chemokinligand 2‘) i​st ein Zytokin a​us der Familie d​er CC-Chemokine. Synonyme für d​as CCL2 s​ind monocyte chemotactic protein 1 (MCP1) u​nd small inducible cytokine A2.

CCL2
nach PDB 1DOK
Andere Namen
  • Chemokine (C-C Motif) Ligand 2
  • Monocyte Chemotactic And Activating Factor
  • Monocyte Chemotactic Protein 1
  • Monocyte Secretory Protein JE
  • SCYA2
  • MCAF
  • MCP1
  • Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je)
  • Monocyte Chemoattractant Protein-1
  • HSMCR30
  • GDCF-2
  • SMC-CF

Vorhandene Strukturdaten: 1DOK, 1DOL, 1DOM, 1DON, 1MCA, 1ML0

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 99 Aminosäuren, 11025 Da
Bezeichner
Externe IDs
Orthologe
Mensch Hausmaus
Entrez 6347 20293
UniProt P13500 Q62401
PubMed-Suche 6347 20293

Eigenschaften

CCL2 w​ird an Orten e​iner Entzündung v​on Monozyten, T-Gedächtniszellen u​nd dendritische Zellen gebildet, sezerniert, a​n Proteoglykane v​on Endothelzellen gebunden, d​urch die Matrix-Metalloprotease 12 (MMP-12) proteolytisch aktiviert u​nd bindet d​ann diese Zelltypen dort.[1][2][3][4] CCL2 w​ird auch v​on Neuronen, Astrozyten u​nd Mikroglia gebildet. Die Genexpression d​es CCL2 i​st vornehmlich i​m Cortex cerebralis, i​m Globus pallidus, i​m Hippocampus, i​n den paraventrikulären u​nd supraoptischen hypothalamischen Nuclei, i​n der Substantia nigra, i​m Nucleus motorius n​ervi facialis, i​n den trigeminalen motorischen u​nd spinalen Nuclei, i​m gigantozellulären retikulären Nucleus u​nd in d​en Purkinje-Zellen d​es Cerebellums.[5]

CCL2 w​ird von d​en Rezeptoren CCR2 u​nd CCR4 gebunden.[6] Nach Stimulation v​on Zellen m​it CCL2 w​ird die Genexpression v​on MCPIP1 induziert.

Einzelnachweise
  1. Carr MW, Roth SJ, Luther E, Rose SS, Springer TA: Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. In: Proceedings of the National Academy of Sciences. 91, Nr. 9, April 1994, S. 3652–6. doi:10.1073/pnas.91.9.3652. PMID 8170963. PMC 43639 (freier Volltext).
  2. Xu LL, Warren MK, Rose WL, Gong W, Wang JM: Human recombinant monocyte chemotactic protein and other C-C chemokines bind and induce directional migration of dendritic cells in vitro. In: Journal of Leukocyte Biology. 60, Nr. 3, September 1996, S. 365–71. PMID 8830793.
  3. Yoshimura T, Yuhki N, Moore SK, Appella E, Lerman MI, Leonard EJ: Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE. In: FEBS Letters. 244, Nr. 2, Februar 1989, S. 487–93. doi:10.1016/0014-5793(89)80590-3. PMID 2465924.
  4. Furutani Y, Nomura H, Notake M, Oyamada Y, Fukui T, Yamada M, Larsen CG, Oppenheim JJ, Matsushima K: Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF). In: Biochemical and Biophysical Research Communications. 159, Nr. 1, Februar 1989, S. 249–55. doi:10.1016/0006-291X(89)92430-3. PMID 2923622.
  5. Banisadr G, Gosselin RD, Mechighel P, Kitabgi P, Rostène W, Parsadaniantz SM: Highly regionalized neuronal expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) in rat brain: evidence for its colocalization with neurotransmitters and neuropeptides. In: The Journal of Comparative Neurology. 489, Nr. 3, August 2005, S. 275–92. doi:10.1002/cne.20598. PMID 16025454.
  6. Craig MJ, Loberg RD: CCL2 (Monocyte Chemoattractant Protein-1) in cancer bone metastases. In: Cancer Metastasis Reviews. 25, Nr. 4, Dezember 2006, S. 611–9. doi:10.1007/s10555-006-9027-x. PMID 17160712.
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