Vav-Proteine

Vav-Proteine s​ind GTP-Austauschfaktoren für Rho-GTPasen. Dadurch wirken s​ie in d​er Signalleitung v​on Zellen. In Säugezellen unterscheidet m​an drei verschiedene Vav-Proteine. Während Vav-1 a​uf hematopoetische Zellen beschränkt ist,[1] werden Vav-2 u​nd Vav-3 i​n verschiedenen Zelltypen exprimiert.[2][3] Alle d​rei enthalten e​ine DH (Dbl-homology)-Domäne, d​ie den GTP-Austausch i​n kleinen Rho-GTPasen katalysiert, e​ine PH (pleckstrin-homology)-Domäne u​nd eine SH2-Domäne, d​ie von z​wei SH3-Domänen eingefasst ist.[4]

Vav-Proteine des Menschen
Gen-NameUniProtAminosäurenOMIMKommentar
VAV1 P15498845164875Zinkfinger, Protoonkogen
VAV2 P527358476004283 Isoformen, Zinkfinger, Angiogenese
VAV3 Q9UKW48786055412 Isoformen, Zinkfinger, Angiogenese

Einzelnachweise
  1. X. R. Bustelo, S. D. Rubin, K. L. Suen, D. Carrasco, M. Barbacid: Developmental expression of the vav protooncogene. In: Cell Growth & Differentiation: the Molecular Biology Journal of the American Association for Cancer Research, 1993, 4(4), S. 297–308, PMID 8494792
  2. K. E. Schuebel et al.: Isolation and characterization of murine vav-2, a member of the vav family of proto-oncogenes. In: Oncogene, 13, 1996, S. 363–371
  3. Nieves Movilla, Xosé R. Bustelo: Biological and Regulatory Properties of Vav-3, a New Member of the Vav Family of Oncoproteins. In: Molecular and Cellular Biology, November 1999, Vol. 19, No. 11, S. 7870–7885
  4. Bustelo et al.: Regulatory and signaling properties of the Vav family. In: Mol. Cell Biol., 20, 2000, S. 1461–1477
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