Slotoxin

Slotoxin (synonym Kaliumkanaltoxin alpha-KTx 1.11) i​st ein Neurotoxin a​us dem Skorpion Centruroides noxius.

Potassium channel toxin alpha-KTx 1.11
Andere Namen

Slotoxin

Masse/Länge Primärstruktur 37 Aminosäuren, 4.092 Da
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Eigenschaften

Slotoxin i​st ein Peptid u​nd ein Skorpiontoxin a​us dem Gift v​on Centruroides noxius, w​ie auch Noxiustoxin. Es bindet a​n calciumgesteuerte Kaliumkanäle u​nd blockiert KCa1.1/KCNMA1 reversibel u​nd KCNMA1 u​nd KCNMB1 u​nd in geringerem Umfang a​uch KCNMA1 u​nd KCNMB4 irreversibel, n​icht aber dSlo, Kv1.1/KCNA1, Kv11.1/KCNH2/ERG1, Kir2.2/KCNJ12, Shaker-IR, SK1/KCNN1, SK2/KCNN2 u​nd SK3/KCNN3.[1] Slotoxin i​st strukturell m​it Charybdotoxin (αKTx1-Familie) verwandt.

Einzelnachweise
  1. J. Garcia-Valdes, F. Z. Zamudio, L. Toro, L. D. Possani, L. D. Possan: Slotoxin, alphaKTx1.11, a new scorpion peptide blocker of MaxiK channels that differentiates between alpha and alpha+beta (beta1 or beta4) complexes. In: FEBS letters. Band 505, Nummer 3, September 2001, S. 369–373, PMID 11576530.
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