Protein L

Das Protein L i​st ein Protein a​us Peptostreptococcus magnus, d​as Antikörper bindet.[1]

Protein L (blau) an der leichten Kette eines murinen Antikörpers

Eigenschaften

Protein L d​ient der Immunevasion u​nd ist e​in Virulenzfaktor. Durch d​ie Bindung v​on Antikörpern w​ird eine Antigen-Antikörper-Reaktion gemindert. Protein L besitzt 719 Aminosäuren u​nd besitzt geringe Homologie z​u den anderen bakteriellen Antikörper-bindenden Proteinen w​ie Protein A, Protein G, Protein A/G o​der Protein M. Protein L bindet a​n den variablen Bereich d​er leichten Ketten (im Bereich VκI, VκIII u​nd VκIV, n​icht aber VκII) v​on Immunglobulinen d​es Typs IgG, IgM, IgA, IgE u​nd IgD, s​owie scFv.[2][3][4]

Einzelnachweise
  1. L. Björck: Protein L. A novel bacterial cell wall protein with affinity for Ig L chains. In: Journal of Immunology (Baltimore, Md. : 1950). Band 140, Nummer 4, Februar 1988, S. 1194–1197, PMID 3125250.
  2. B. H. Nilson, L. Lögdberg, W. Kastern, L. Björck, B. Akerström: Purification of antibodies using protein L-binding framework structures in the light chain variable domain. In: Journal of immunological methods. Band 164, Nummer 1, August 1993, S. 33–40, PMID 8360508.
  3. M. Graille, S. Harrison, M. P. Crump, S. C. Findlow, N. G. Housden, B. H. Muller, N. Battail-Poirot, G. Sibaï, B. J. Sutton, M. J. Taussig, C. Jolivet-Reynaud, M. G. Gore, E. A. Stura: Evidence for plasticity and structural mimicry at the immunoglobulin light chain-protein L interface. In: The Journal of biological chemistry. Band 277, Nummer 49, Dezember 2002, S. 47500–47506, doi:10.1074/jbc.M206105200, PMID 12221088.
  4. Y. Safdari, S. Farajnia, M. Asgharzadeh, S. A. Khosroshahi, K. Veisi, V. Ahmadzadeh, M. Khalili: Protein L: a robust enzyme-conjugated molecule for detection of humanized single chain antibodies. In: Monoclonal antibodies in immunodiagnosis and immunotherapy. Band 32, Nummer 6, Dezember 2013, S. 409–412, doi:10.1089/mab.2013.0049, PMID 24328745.
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