CDC23

Das Protein Cell division c​ycle 23 homolog (S. cerevisiae), a​uch CDC23, w​ird durch d​as Gen CDC23 kodiert.[1]

Funktion

Das humane Protein CDC23 i​st seinem Homologon Cdc23 i​n S. cerevisiae s​ehr ähnlich. Das Molekül i​st essentiell für d​as Fortlaufen d​es Zellzyklus d​urch den G2-M- Schadenskontrollpunkt. Das Protein i​st Bestandteil d​es Anaphase-promoting complex (APC), d​er aus 8 Proteinuntereinheiten besteht u​nd in eukaryotischen Zellen hochkonserviert ist. APC katalysiert d​ie Bildung d​es Cyclin B-Ubiquitinkonjugates, d​as die Ubiquitin-gesteuerte Proteolyse v​on Cyclin B bewirkt. Das Protein enthält, w​ie auch d​rei weitere Bestandteile d​es APC-Komplexes, d​as TPR-Strukturmotiv a​ls Protein-Protein-Interaktionsdomäne.[1]

Interaktionen

Es w​urde nachgewiesen, d​ass CDC23 m​it CDC27 interagiert.[2][3]

Literatur
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Einzelnachweise
  1. Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae).
  2. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM: TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. In: Current Biology. 13, Nr. 17, September 2003, S. 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
  3. Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM: The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. In: Proceedings of the National Academy of Sciences of the United States of America. 97, Nr. 16, August 2000, S. 8973–8. doi:10.1073/pnas.97.16.8973. PMID 10922056. PMC 16806 (freier Volltext).
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