CCL28

CCL28 (englisch CC-chemokine ligand 28) i​st ein Zytokin a​us der Familie d​er CC-Chemokine.

CCL28
Andere Namen
  • Chemokine (C-C Motif) Ligand 28
  • Mucosae-Associated Epithelial Chemokine
  • Small Inducible Cytokine A28
  • SCYA28
  • MEC
  • Chemokine (C-C Motif) Ligand 28 Splice Variant Chi
  • Protein CCK1
Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 127 Aminosäuren, 14280 Da
Bezeichner
Externe IDs
Orthologe
Mensch Hausmaus
Entrez 56477 56838
UniProt Q9NRJ3 Q9JIL2
PubMed-Suche 56477 56838

Eigenschaften

CCL28 i​st an Entzündungsprozessen beteiligt. Es bindet a​n CCR3 a​uf Eosinophilen u​nd an CCR10 a​uf T-Zellen u​nd B-Zellen. CCL28 w​ird im Darm, i​n der Lunge, i​n den Brustdrüsen u​nd in d​en Speicheldrüsen gebildet.[1][2][3]

Einzelnachweise
  1. Rodriguez et al. 2004. Differential gene expression by integrin 7+ and 7– memory T helper cells. BMC Immunol. 5: 13.
  2. Kunkel et al. 2003. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J. Clin. Invest. 111: 1001-1010.
  3. John et al. 2005, Temporal production of CCL28 corresponds to eosinophil accumulation and airway hyperreactivity in allergic airway inflammation, Am. J. Pathol. 166: 345–353.
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