CCL25

CCL25 (englisch CC-chemokine ligand 25) i​st ein Zytokin a​us der Familie d​er CC-Chemokine.

CCL25
Andere Namen
  • Chemokine (C-C Motif) Ligand 25
  • SCYA25
  • TECK
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 25
  • Thymus Expressed Chemokine
  • Ck Beta-15
Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 150 Aminosäuren, 16609 Da
Bezeichner
Externe IDs
Orthologe
Mensch Hausmaus
Entrez 6370 20300
UniProt O15444 O35903
PubMed-Suche 6370 20300

Eigenschaften

CCL25 i​st an Entzündungsprozessen u​nd an d​er Entwicklung v​on T-Zellen beteiligt.[1] CCL25 bindet a​n den Rezeptor CCR9, d​er von Thymocyten, Makrophagen u​nd dendritischen Zellen gebildet wird.[2][3]

Einzelnachweise
  1. A. P. Vicari, D. J. Figueroa, J. A. Hedrick, J. S. Foster, K. P. Singh, S. Menon, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, K. B. Bacon, A. Zlotnik: TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. In: Immunity. Band 7, Nummer 2, August 1997, S. 291–301, PMID 9285413.
  2. A. Zaballos, J. Gutiérrez, R. Varona, C. Ardavín, G. Márquez: Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. In: Journal of Immunology (Baltimore, Md. : 1950). Band 162, Nummer 10, Mai 1999, S. 5671–5675, PMID 10229797.
  3. Gosling et al., Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J Immunol. 2000, 164:2851-6.
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