Landomycine

Die Landomycine gehören zur Gruppe der Angucycline und werden aus Streptomyces isoliert. Sie werden auf die Verwendung als Antikrebsmedikamente untersucht.

Landomycin A

Landomycin B

Literatur

T. Henkel, J. Rohr, J. M. Beale, and L. Schwenen: Landomycins, new angucycline antibiotics from Streptomyces sp. I. Structural studies on landomycins A-D. The Journal of Antibiotics, 1990, 43 (5), S. 492–503. PMID 2358402. doi:10.7164/antibiotics.43.492.
O. V. Tymchyk, B. P. Matseliukh, V. I. Lavrinchuk: Sensitivity of Streptomyces globisporus 3-1–a highly active producer of landomycin E to its own and the other polyketide antibiotics. Mikrobiolohichnyi zhurnal. Band 66, Nummer 2, 2004 Mar-Apr, S. 69–73, PMID 15208856.
K. A. Shaaban, S. Srinivasan, R. Kumar, C. Damodaran, J. Rohr: Landomycins P-W, cytotoxic angucyclines from Streptomyces cyanogenus S-136. Journal of Natural Products. Band 74, Nummer 1, Januar 2011, S. 2–11, doi:10.1021/np100469y, PMID 21188999, PMC 3070852 (freier Volltext).
K. A. Shaaban, C. Stamatkin, C. Damodaran, J. Rohr: 11-Deoxylandomycinone and landomycins X-Z, new cytotoxic angucyclin(on)es from a Streptomyces cyanogenus K62 mutant strain. The Journal of Antibiotics. Band 64, Nummer 1, Januar 2011, S. 141–150, doi:10.1038/ja.2010.121, PMID 20978514, PMC 3030652 (freier Volltext).

Weblinks

Entwicklung neuer Antikrebsmedikamente: Landomycin A, 13. Oktober 2015.

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