Kaliotoxin 1

Kaliotoxin 1 (synonym Kaliumkanaltoxin alpha-KTx 3.5) i​st ein Toxin a​us dem Skorpion Androctonus australis.

Potassium channel toxin alpha-KTx 3.1
Andere Namen

Kaliotoxin 1, KTx 1

Vorhandene Strukturdaten: PDB 1KTX, PDB 1XSW, PDB 2KTX

Masse/Länge Primärstruktur 38 Aminosäuren, 4.156 Da
Bezeichner
Externe IDs

Eigenschaften

Kaliotoxin 1 i​st ein Protein u​nd Skorpiontoxin a​us A. australis, w​ie auch Kaliotoxin 2. Es bindet u​nd hemmt spannungsgesteuerte Kaliumkanäle v​om Typ Kv1.3[1] (Kd = 0,65 nM), Kv1.6.[2] u​nd Kv1.1/KCNA1 (Kd = 41 nM) s​owie KCa1.1/KCNMA1 (Ki = 1560 nM), n​icht aber Kv1.2/KCNA2, Kv1.5/KCNA5 u​nd Kv3.1/KCNC1. Kaliotoxin 1 u​nd 2 s​ind strukturell a​m nächsten m​it Agitoxin 1, Agitoxin 2 u​nd Agitoxin 3 verwandt.[3]

Einzelnachweise
  1. A. Lange, K. Giller, S. Hornig, M. F. Martin-Eauclaire, O. Pongs, S. Becker, M. Baldus: Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR. In: Nature. Band 440, Nummer 7086, April 2006, S. 959–962, doi:10.1038/nature04649, PMID 16612389.
  2. O. V. Nekrasova, A. D. Volyntseva, K. S. Kudryashova, V. N. Novoseletsky, E. A. Lyapina, A. V. Illarionova, S. A. Yakimov, Y. V. Korolkova, K. V. Shaitan, M. P. Kirpichnikov, A. V. Feofanov: Complexes of Peptide Blockers with Kv1.6 Pore Domain: Molecular Modeling and Studies with KcsA-Kv1.6 Channel. In: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. Band 12, Nummer 2, Juni 2017, S. 260–276, doi:10.1007/s11481-016-9710-9, PMID 27640211.
  3. Hervé Rochat: Animal Toxins. Springer Science & Business Media, 2000, ISBN 978-3-764-35983-6, S. 184.
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